Eperisone

Molecular formula C17H25NO Molecular weight 259.39 CAS Registry No 64840-90-0 Merck Index 13,3637 

Sample preparation Mix 1 mL water, 100 irL 1 ig mL IS in MeOH, and 1 mL 1 M pH 7.2 phosphate buffer with 100 pL plasma, add 4 mL diethyl ether, extract, repeat extraction. Combine the organic layers and add them to 200 pL 100 mM HCl, extract, inject a 70 pL aliquot of the aqueous layer. 

Mobile phase MeCN 5 mM pH 2.5 sodium dodecyl sulfate 50 50 

Matsunaga, M. Uemura, Y. Yonemoto, Y. Kanai, K. Etoh, H. Tanaka, S. Atsuta, Y. Nishizawa, Y. Yamanishi, Y. Long-lasting muscle relaxant activity of eperisone hydrochloride after percutaneous administration in rats, Jpn.J.Pharmacol., 1997, 73, 215-220. 

Mobile phase Gradient. MeCNilO mM pH 4.2 potassium phosphate buffer 0 100 for 2 min, to 75 25 over 7.5 min, maintain at 75 25 for 5.5 min. Isocratic. MeCN bufifer 20 80 Flow rate 1.5 

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Acebutorol, arotinolol, atropine, bupivacaine, clorprenaline, denopamine, eperisone, epinastine, etirefline, fenoterol, homatropine, ketamine, metanephrine, metoprolol, mexiletine, nicardipine, oxyphencyclimine, phenylephrine, pindolol, primaquine, promethazine, sulpiride, ter-butaline, tolperizone, trihexyphenidyl, trimebutine, trimetoquinol, trimipramine, verapamil 81... 

Alimemazine, chlorpheniramine, eperisone, pindolol, prenylamine, promethazine, thioridazine, tolperisone, trimipramine 88... 

FIGURE 15 Chromatograms of eperisone enantiomers on ovomucoid CSP using phosphate buffer (10mM, pH 5.0)-2-propanol (95 5, v/v) as the mobile phase in electro-kinetic chromatography. (From Ref. 138.)... 

C1120 50-00-0) see Aciclovir Alclofenac Alminoprofen Alpidein Altretamine Amodiaquine Azithromycin Bromperidol Budipine Calcium pantothenate Cicloxilic acid Clofedanol, Clomocycline Cortivazol Dextropropoxyphene Dichlorophen Domiphen bromide Edetic acid Eperisone Eprozincrl Etacrynic acid ... 

Eperisone hydrochloride is a centrally acting muscle relaxant useful in the management of various spastic conditions including cerviced spondylosis and cerebral palsy. It is structuredly related to tolperisone. 

In rat studies, there was mutual ehiral inversion both in vivo and in vitro in plasma and blood [129]. The mechanisms for this inversion are not clear. Lanperisone and eperisone are newly developed members of this group of drugs with lanpersione being developed as a pure R(—)-enantiomer. Currently no information regarding bioinversion or conformation stabihty of these drugs is available. 

P450 2J2 has also been found to be rather proficient in the oxidation of a number of drags, including terfenadine [1129, 1148], ebastine [1149], astemizole [1150, 1151], hydroxyebas-tine and carebastine [1152], eperisone [1153], vorapaxar [1154], amiodarone [1155], albendazole and fenbendazole [833], thioridazine, me-... 

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