Eosinophils into airways

Inflammatory disease associated with bronchial hyperactivity (BHR), bronchospasm, T mucus secretion, edema, and cellular infiltration. Early asthmatic responses (EAR) lasting from 30 to 60 min are associated with bronchospasm from the actions of released histamine and leukotrienes late asthmatic responses (LAR) involve infiltration of eosinophils and lymphocytes into airways - > bronchoconstriction and inflammation with mucus plugging. 

Late asthmatic responses (LAR) involve infiltration of eosinophils and lymphocytes into airways bronchoconstriction and inflammation with mucous plugging. 

Shi H, Qin S, Huang G, et al. Infiltration of eosinophils into the asthmatic airways caused by interleukin 5. Am J Respir Cell Mol Biol 1997 16 220-224. 

Fujiwara M, Hirose K, Kagami S. Takatori H. Waka-shin H, Tamachi T, Watanabe N. Saito Y. Iwamoto I. Nakajima H T-bet inhibits both Th2 cell-mediated eosinophil recruitment and Th17 cell-mediated neutrophil recruitment into the airways. J Allergy Chn Immunol 2007 119 662-670. 

K6. Kumano, K., Nakao, A., Nakajima, H., Hayashi, F., Kurimoto, M., Okamura, H., Saito, Y., and Iwamoto, I., Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am. J. Respir. Crit. Care Med. 160, 873-878 (1999). 

Morokata T, Suzuki K, Ida K, Yamada T. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDFl mice. Immunol Lett. 2005 98 161-165. 

Mechanism of Selective Eosinophil Recruitment into the Airways 87... 

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