Eosinophilia beta-lactams

Virtually all beta-lactam antibiotics can cause eosinophilia, either isolated or in the context of very different reactions. 

Acute renal insufficiency, with or without skin rash and eosinophilia, has been reported with various beta-lactam antibiotics, most often with methicUhn. Hence, the designation methicUhn-nephritis is stiU sometimes used. The pathogenesis is largely unknown and is different from the... 

The underlying mechanism of a series of clinical entities associated with beta-lactams, such as maculopapular rash, drug fever, eosinophilia, serum sickness-like disease, vesicular and bullous skin reactions, erythema nodosum, and acute interstitial nephritis, is suspected to be immunological but is still largely unknown. 

Various antibiotics, in particular sulfonamides, beta-lactam compounds, tetracycline and ethambutol, may induce pulmonary toxicities, which usually consist of pulmonary infiltrates with eosinophilia. Dmg-induced lupus states have also been reported with minocychne and tetracycline, nalidixic acid, sulfonamides, and nitrofurantoin (1). 

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