Enzymic Synthesis of Oligosaccharides

Zehavi U, Herchman M, Enzymic synthesis of oligosaccharides on a polymer support, light-sensitive, water-soluble substituted poly(vinyl alcohol), Carbohydr. Res., 128 160-164, 1984. 

Herrmann GF, Wang P, Shen G-J, Wong C-H. Recombinant whole cells as catalysts for enzymic synthesis of oligosaccharides and glycopeptides. Angew Chem 1994 106 1346-1347. 

Some Aspects of Enzymic Synthesis of Oligosaccharides Employing Acceptor Saccharides Attached to Polymer Carriers... 

Sucrose + inorganic phosphate = a-n-glucose 1-phosphate -f- n-fructose Using a-D-glucose 1-phosphate and D-fructose, they prepared sucrose, which was isolated in crystalline form. (See Enzymic synthesis of oligosaccharides, p. 520). 

Enzymic synthesis of oligosaccharides by transglycosylation (a) General discussion... 

This great structural variety, however, complicates the specific biosynthesis of complex oligosaccharides. In general, the formation of each saccharide linkage requires specific enzymes ( one linkage—more than one enzyme ) and thus, in comparison with the enzymic synthesis of proteins and nucleic acids, much more effort is needed. 

Subsequently, a combined organic-enzymic approach was proposed for the synthesis of oligosaccharides. By common organic procedures, a... 

Enzyme-Catalyzed Solid-Phase Synthesis of Oligosaccharides I 391... 

Schuster M, Wang P, Paulson JC, Chi-Huey WongSchuster. Solid-phase chemical-enzymic synthesis of glycopeptides and oligosaccharides, J. Am. Chem. 

Chappell MD, Halcomb RL. Enzyme-catalyzed synthesis of oligosaccharides that contain functionalized sialic acids. J. Am. Chem. Soc. 1997 119 3393-3394. 

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