Enzyme responsive polymers enzymatically degradable

While the previous section dealt with the structural elements that define enzyme-responsive polymers, here we will introduce different methods that can be used to integrate an enzyme-responsive functionality with a polymeric material. These methods are placed into three groups. The first method deals with the preparation of enzymatically degradable polymers, the second introduces strategies to incorporate enzyme-responsive linkers into the polymer and the third explores ways to prepare enzyme-responsive polymers enzymatically. 

The Mato Bi samples made of starch and poly-e-caprolactone or cellulose derivatives were studied. Enzymatic degradation of Mater Bi samples was investigated by incubating the biomaterial in concentrated trypsin solution to simulate the in vitro interaction between the polymer and the degradative enzymes during the inflammatory response. 

To date, two main approaches have been adopted for developing enzyme-responsive materials. In the first and most common approach, the nanocarrier itself is sensitive to enzymatic transformation. This is achieved by the use of either an enzymatically degradable polymer or enzymatically sensitive linkers between the drug and the polymer. 

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