Enzymatic removal of oxygen radicals

SODs have been used in animal models to limit damage by direct injection at sites of inflammation with effective, albeit transient, effects and the use of SODs as potential therapeutic agents has been the focus of intense debate [25], Recently, using a recombinant manganese SOD in two different experimental models of inflammation, we demonstrated an anti-inflammatory effect and showed correct dosing to be critical [26]. 

Caeruloplasmin (Cp) is the major copper-containing protein of human serum and is an acute phase reactant, being synthesised in increased amounts by the liver in inflammation [27]. Several groups have suggested that the pool of non-Cp-bound copper, capable of catalysing oxidative reactions, was elevated in rheumatoid extracellular fluids [28,29], However, these reports are likely to be artifactual, since Cp readily loses its copper during storage-induced oxidation/proteolysis [30,31]. 

Chelation of catalytic iron and free radical scavengers 

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