Environmental factors affecting metabolism

Hodgson E. Chemical and environmental factors affecting metabolism of xenobiotics. In Hodgson E, Levi PE, eds. Introduction to Biochemical Toxicology. 2nd ed. Connecticut Appleton-Lange, 1994. Jakoby WE, ed. Enzymatic Basis of Detoxication. New York Academic Press, 1980. 

Hodgson, E. (1994). Chemical and environmental factors affecting metabolism of xeno-biotics. In Introduction to Biochemical Toxicology (Hodgson. L. and Levi. P. E.. eds). eh. 7, pp. 153-175. Appleton and Lange. Norwalk, CT. 

Fraser, H. S., Mucklow, J. C. et al. (1979). Environmental factors affecting antipyrine metabolism in London factory and office workers. Br. J. Clin. Pharmacol., 7(3), 237-43. 

Mucklow JC, Fraser HS, Bulpitt CJ, et al Environmental factors affecting paracetamol metabolism in London factory and office workers. Br J Clin Pharmacol 10 67-74,1980... 

Introduction - The Interest In drug metabolism has steadily Increased during the last several years. In addition to routine studies of absorption, excretion, and the metabolic fate of Individual drugs, more attention has been given to drug Interactions and to various environmental factors affecting drug metabolism. 

A second scan of Callistemon tissue examining a sample collected from the same plant two months later in the season is shown in Figure 3 (solid line). This curve has the same overall shape as the earlier scan, but metabolic rates are somewhat lower and r, , is shifted to a higher temperature. Similar shifts in properties with plant age, nutrient stress, or other environmental factors affecting plant yields can equally well be studied with these methods. 

Mannering, G.J. Properties of cytochrome P-1+50 as affected by environmental factors Qualitative changes due to administration of polycyclic hydrocarbons. Metabolism... 

The duration of acclimation is affected by several environmental factors, such as temperature, pH, aeration status, and nutrients. The concentration of the compound that is being metabolized greatly affects the length of time before a decline in its concentration is detectable. The rate of biodegradation of trace compounds increases with concentration, but because compound loss is usually determined and not C02 or product formation, the low precision of analysis leads to data indicating a longer acclimation at higher concentration [104,106,113,128]. 

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