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Paracetamol metabolism

Free radical-induced cell damage Figure 6.34 Paracetamol metabolism... [Pg.205]

Prescott LF, Wright N. The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol 1973 49(4) 602-613. [Pg.402]

Miners JO, Attwood J, Birkett DJ. Influence of sex and oral contraceptive steroids on paracetamol metabolism. Br J Clin Pharmacol 1983 16(5) 503-9. [Pg.252]

Prescott LF, Critchley JAJH, Bulali-Mood M, et al. Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol 1981 12 149-153. [Pg.706]

F. Kamali, The effect of probenecid on paracetamol metabolism and pharmacokinetics. Eur. J. Clin. Pharmacol. 45 551-553, 1993. [Pg.369]

As with most medications, no robust assessment of the use of paracetamol in liver disease has been performed, although small studies of paracetamol metabolism in various forms of liver disease have been undertaken. Although limited, the results of some of these studies are summarised below. [Pg.177]

Mucklow JC, Fraser HS, Bulpitt CJ, et al Environmental factors affecting paracetamol metabolism in London factory and office workers. Br J Clin Pharmacol 10 67-74,1980... [Pg.111]

Moldeus P (1978) Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochem Pharmacol 27 2859-2863... [Pg.402]

The metabolisim of paracetamol is increased in patients taking enzyme-inducing antiepileptics (carbamazepine, phenytoin, pheno-barbital, primidone). Isolated reports describe unexpected hepatotoxicity in patients taking phenobarbital, phenytoin, or carbamazepine after taking paracetamol. Valproate does not appear to affect paracetamol metabolism. [Pg.191]

Baraka OZ, Truman CA, Ford JM, Roberts CJC. The effect of propranolol on paracetamol metabolism in man. BrJ Clin Pharmacol (1990) 29, 261-4. [Pg.197]

A patient taking zidovudine and co-trimoxazole took 3.3 g of paracetamol over 36 hours. Within 2 days he developed severe hepatotoxicity, and as other causes were excluded, the reaction was attributed to the paracetamol. The authors suggested that zidovudine may have augmented the paracetamol toxicity. However, in a single-dose study, reduced paracetamol glucuronidation and increased formation of hepatotoxic metabolites was seen in patients with advanced HIV infection compared with healthy HIVpositive subjects and those without HIV, and this effect was independent of zidovudine use.In contrast, in another study, disease state (AIDS versus healthy HIV-positive subjects) was not found to alter paracetamol metabolism, and zidovudine was found to increase paracetamol glucuronidation in some patients."... [Pg.803]

See other pages where Paracetamol metabolism is mentioned: [Pg.204]    [Pg.163]    [Pg.401]    [Pg.242]    [Pg.117]    [Pg.119]    [Pg.55]    [Pg.1669]    [Pg.2689]    [Pg.285]    [Pg.667]    [Pg.74]    [Pg.194]    [Pg.197]    [Pg.438]   
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See also in sourсe #XX -- [ Pg.127 ]

See also in sourсe #XX -- [ Pg.86 , Pg.87 , Pg.276 , Pg.277 ]



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