Enumeration strategy

Cell enumeration strategies based on impedance detection have been applied academically and commercially, particularly in the HIV monitoring application space. Watkins et al. [5] developed... 

The divide and conquer enumeration strategy used here calls for determining the number of different substituent patterns possible on each backbone atom. There are two different kinds of backbone atoms in n-hexane four central methylenes and two terminal methyls. With the divide and conquer method, these are enumerated separately then combined later. 

TDM can detect interindividual variability in pharmacokinetics that can determine clinical outcome (83, 84, 85, 86, 87, 88 and 89). It is essentially a refinement of the traditional approach of adjusting dose based on clinical response. Using this strategy, the clinician titrates the dose based on an assessment of efficacy versus the development of nuisance or toxic effects. The discussion in this chapter has enumerated those pharmacokinetic factors that may produce variable clinical outcomes in different patients taking the same medication. TDM can be used to detect those differences among patients to guide rational dose adjustment. 

OptiDOCK Uses the seed and grow strategy to first dock representative compounds spanning the chemical space of the library and subsequently use an optimal core for library enumeration (83)... 

As stated before, PGVL is too large to be fully enumerated practically. Therefore our strategy is to find a way to focus in a just-in-time manner on much smaller sub-regions ( 104) of PGVL for subsequent on-the-fly enumeration followed by standard similarity search against the same query molecule. It is intuitively evident that a virtual compound space built from parallel synthesis reaction protocols has inherent array structures in the form of implicit arrays of related just-in-time enumerated compounds, even if those compounds do not have their molecular structures yet enumerated at the time this inherent array structure is exploited. 

The assessment of the number of experimental metastases, typically pulmonary metastases, following i.v. injection of a single cell suspension of tumor cells or collagenase-digested primary tumor provides the most common outcomes. Multiple strategies may be used for this enumeration including... 

The thermodynamic parameters in Table II can be used to calculate the thermodynamic quantities necessary to define the partition function. Essentially, the strategy to calculate the folding/unfolding partition function from structural data involves the identification and enumeration of states and the assignment of Gibbs free energies to those states. Once this task is accomplished, the evaluation of the partition function is straightforward, as illustrated in Fig. 4. 

Thus, one must develop a strategy to locate quickly the better alternatives for these virtually infinite problems, a strategy which cannot require one to enumerate all options. 

To solve a problem of this first class is to perform a tree search. Ponton and Donaldson use heuristics to select each next match and find only one solution, often a good one but not always. Pho and Lapidus propose a total enumeration scheme, but, for very large problems (10 streams), suggest a fallible lookahead strategy to eliminate branches. Lee, Masso and Rudd,... 

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