Enkephalin ligand

Prototypic ligands Morphine Met/leu-enkephalin Ethylketocyclacozine Nociceptin/OFQ... 

Neprilysin (enkephalinase, Endopeptidase-24.11, neutral endopeptidase, NEP, EC 3.4.24.11) bears considerable resemblance to other zinc-containing metallopeptidases it is an oligopeptidase that hydrolyzes enkephalins and a range of other active peptides. Enkephalins are endogenous ligands of opiate receptors, and the prolongation of their action via inhibition of enkephalinase... 

Substances with a neuromodulatory effect on brain neurotransmitters by direct actions of specific receptors that modify the actions of the transmitters listed include prostaglandins, adenosine, enkephalins, substance P, cholecystokinin, endorphins, endogenous benzodiazepine receptor ligands, and possibly histamine. CNS, central nervous system. NMDA, N-methyl-D-aspartate. Strych, strychnine. 

Delta receptor activation also produces analgesia, but it can also cause seizures as well. Delta receptors normally bind to a class of endogenous ligands known as enkephalins, but unlike mu receptors, information about delta receptors is limited. Enkephalins are peptides that are produced by the pituitary gland. Several different enkephalins have been identified. [3-Enkephalin resembles opiates because when it binds to a delta receptor, it relieves pain.11... 

Further radiolabeled ligand-binding assays have been reported for a wide variety of analytes, namely morphine and leu-enkephaline [30], (S )-propanolol [33], atra-zine [47], 17-jS-estradiol [59], 2,4-dichlorophenoxyacetic acid (2,4-D) [32], yohimbine and corynanthine [60], and corticosterone/cortisol [29]. Other assays are summarized in Table 3. 

The first endogenous ligands for the opioid receptors were isolated by Kosterlitz and Hughes and were found to be the pentapeptides methionine and leucine enkephalin (meta- and leu-enkephalin). The structures of these,... 

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