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Zinc fingers enhancer-binding protein

Morinaga, T., Yasuda, H., Hashimoto, T Higashio, K., and Tamaoki, T. (1991). A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. Mol. Cell. Biol. 11 6041-6049. [Pg.85]

Omichinski, J. G., Clore, G. M., Appella, E., Sakaguchi, K., and Gronenborn, A. M. (1990). High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry 29, 9324-9334. [Pg.72]

Proteins with the helix-turn-helix or leucine zipper motifs form symmetric dimers, and their respective DNA binding sites are symmetric palindromes. In proteins with the zinc finger motif, the binding site is repeated two to nine times. These features allow for cooperative interactions between binding sites and enhance the degree and affinity of binding. [Pg.389]

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