Enhanced-resolution scan

B) mass spectrum from positive enhanced resolution scan finds the clozapine-GSH adduct at m/z 632 (C) enhanced product ion spectrum of clozapine-GSH adduct at m/z 632. 

Enhanced resolution Q3 single MS (ER) RE only No fragment Trap/scan... 

The emergence of high-resolution LC-MS technologies has greatly facilitated metabolite identification tasks with enhanced resolution, high mass accuracy, and high sensitivity in a full-scan mode (Meyer et al., 1996 Yoshitsugu et al., 1999 ... 

Neri, L. M., Cinti, C., Santi, S., Marchisio, M., Capatini, S., and Maraldi, N. M. (1997) Enhanced resolution of specific chromosome and nuclear regions by reflectance laser scanning confocal microscopy. Histochem. Cell. Biol. 107, 97-104. 

At this stage, different MS experiments can be performed. In the full-scan mode, ions of different m/z are consecutively ejected from the trap towards the external detector by ramping the RF voltage at the ring electrode. Resonant ion ejection may be supported by additional waveforms applied to the end-cap electrodes. Ion ejection can be achieved with unit-mass resolution, or at enhanced resolution by slowing down the scan rate [42]. 

A line-scan of the illumination laser light has been used to enhance the scan rate, at least compared to the point-by-point scan [18, 21-25]. It remains compatible with a spectral acquisition of high resolution, since total fluorescence from the linear region can be projected onto the slit of an imaging polychromator. A CCD camera at the exit port records the fluorescence intensity as a function of the spatial coordinate and the wavelength in the two-dimensional sensitive area of the camera. This method... 

There have been recent reports of new MS configurations for proteomics research, particularly new MS/MS systems. One such development is the combination of MALDI with a Q-TOF mass spectrometer, which enables, besides an enhanced resolution and sensitivity, interesting opportunities for automation [498]. MALDI TOF-TOF has been described by Medzihradski et al. and has the same benefits as MALDI-Q-TOF but is also capable of collisional-induced dissociation (CID) and very fast scan rates [499]. The most recent addition to the repertoire is the... 

Although the mass resolution of commercial instruments is poor (unit mass resolution), substantial improvements can be realized on research instruments by reducing the scan speed and the frequency and amplitude of the resonance ejection signal [44,45]. For example, a resolution of 1.13 x 10 was achieved for a cluster of Csl ions at 3510 u with a 2000-fold decrease in the scan speed [44]. The reduction of the scan rate to 0.1 miq unit/s has led to a further improvement in resolution to 1.2 x 10 for mIq 614 [45]. A zoom scan, in which a narrow window of masses is scanned, is another alternative to enhance resolution. 

Enhanced Resolution Q3 Sihgle MS (ERMS) RF-only No frag Trap/scan... 

McKelvey, K., M. E. Snowden, M. Peruffo, and P. R. Unwin, Quantitative visualization of molecular transport through porous membranes Enhanced resolution and contrast using intermittent contact-scanning electrochemical microscopy. Anal. Chem., Vol. 83, 2011 pp. 6447-6454. 

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