Enhanced fluidity liquid chromatography

Figure 7.5 The Enhanced Fluidity Liquid Chromatography range. This occupies the volume in the phase diagram below the locus of critical temperatures, above and below the locus of critical pressures, and is composed mostly of the less volatile mobile-phase component. Reproduced by permission of the American Chemical Society.

S. V. Olesik, Applications of enhanced-fluidity liquid chromatography in separation science an update , in Unified Chromatography, J. E. Parcher and T. L. Chester (Eds), ACS. Symposium Series 748, American Chemical Society, Wasliington, DC, pp 168-178 (2000). 

In packed column SFC, polar solutes such as amines and carboxylic acids often have too much retention or elute with poor peak shapes when neat carbon dioxide is used as a mobile phase [28, 92]. This is mainly due to the weak solvent strength of neat carbon dioxide compared to a liquid solvent. The use of modifiers is often necessary to enhance the solvating power of the mobile phase in SFC. Various alcohols such as methanol and isopropanol are commonly used modifiers in SFC, but other solvents such as acetonitrile was also utilized [92]. The concentrations of modifiers are usually less than 50%. The technique in which the concentrations of modifiers are greater than 50% is often called enhanced-fluidity liquid chromatography [93]. 

Enantiomers, separation of see chiral forms End-cuts see heart-cuts Enhanced fluidity liquid chromatography (EFLC) 156, 157... 

Lee, S. T. and Olesik, S. V., Normal-phase high-performance liquid chromatography using enhanced fluidity liquid mobile phases, /. Chromatogr. A, 707, 217, 1995. 

Q Enhanced-Fluidity Liquid Mixtures Fundamental Properties and Chromatography... 

Yuan, H.M. and Olesik, S.V. 1997. Supercritical fluid and enhanced-fluidity liquid extraction of phenolics from river sediment. Journal cf Chromatography A, 764, (2), 265-211. 

The use of enhanced-fluidity liquid mixtures of THF and carbon dioxide for Uquid chromatography at the critical condition was examined. For PS polymers, the molec.wt. range that could be analysed at the critical condition was... 

Y. Cui and S. V. Olesik, High-performance liquid chromatography using mobile phases with enhanced fluidity , Anal. Chem. 63 1812-1819 (1991). 

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