Isoprenoid microbes, engineering production

Where natural production is not at sufficient titre and biotransformation is not a viable approach, microbes must be engineered to produce the desired isoprenoid directly from central carbon intermediates. Here we will review engineering approaches for isoprenoid production, focusing on model organisms but also discussing more unusual production strains. We also review some of the economic and practical considerations for isoprenoid bioprocesses, including issues related to feedstock price/availability (particularly important for bulk bioprocesses) and product toxicity (particularly for isoprenoid hydrocarbons with fuel applications). 

Figure 12.2 The biosynthesis of the clavulanic acid pathway [77]. (Reproduced by permission from Macmillan Publishers Ltd M.C.Y. Chang and J.D. Keasling. Production of isoprenoid pharmaceuticals by engineered microbes. Nature Chemical Biology 2 (12) 674-682. London Nature Publishing Group. 2006 Macmillan)...

Chang, M.C. and Keasling, ).D. (2006) Production of isoprenoid pharmaceuticals by engineered microbes. Nat. Chem. Biol, 2, 674-681. 

Production of Industrially Relevant Isoprenoid Compounds in Engineered Microbes... 

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