Energy-dependent Electrospray Tandem Mass Spectrometry

4 Energy-dependent Electrospray Tandem Mass Spectrometry 

Alternatively, the recent introduction of EDESI-MS/MS provides another useful tool for analysing such systems. Tandem mass spectrometry (MS/MS) allows selection of a single ion using one mass analyser then introducing it to a collision cell. Energetic collisions with an inert gas in this cell cause fragmentation of the ion and a daughter ion spectrum is obtained. MS/MS techniques are especially useful for the analysis of complex mixtures, but their application to molecules 

Comparison between the two EDESI maps reveals the expected similarities, but also some marked differences. In particular, the ability to fragment the parent ion within the collision cell is markedly less than that achieved at the skimmer cone. The EDESI map shows that the ion [Ir4H] (in which all CO 

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