Endothelin B receptor

Khodorova A, Navarro B, Jouaville LS et al (2003) Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med 9 1055-1061... 

Endothelin-1, one of the most potent physiologic vasoconstrictors, is an important contributor to HF pathophysiology.9 Endothelin-1 binds to two G-protein coupled receptors, endothelin-A (ET-A) and endothelin-B (ET-B). Endothelin-A receptors mediate vasoconstriction and are prevalent in vascular smooth muscle and cardiac cells. Endothelin-B receptors are expressed on the endothelium and in vascular smooth muscle, and receptor stimulation mediates vasodilation. Levels of ET-1 correlate with HF functional class and mortality. 

The endothelin B receptor is an example of characterization of a homogeneous, affinity purified protein (Roos et al., 1998). Significant progress has been made in the development of techniques for more high-throughput identification of phosphorlyation events. Analysis of large sets of phosphorylated proteins is facilitated by the availability of affinity purification methods such as anti-phosphotyrosine or anti-phosphoserine antibodies or metal affinity chromatography (Neubauer and Mann, 1999 Soskic et al., 1999). These methods are not specific to a particular protein but rather are used to fractionate all proteins that are phosphorylated. 

Rivera A, Rotter MA, Brugnara C. Endothelins activate Ca(2+)-gated K(+) channels via endothelin B receptors in CD-I mouse erythrocytes. Am J Physiol 1999 277 C746-754. 

Fuchs, S., Amiel, J., Claudel, S., Lyonnet, S., Corvol, P., and Pinet, F. (2001) Functional characterization of three mutations of the endothelin B receptor gene in patients with Hirschsprung s disease evidence for selective loss of G(i) coupling. Mol. Med. 7, 115-124. 

Puffenberger EG, Hosoda K, Washington SS, Nakao K, deWit D, Yanagtisawa M, Chakravarti A. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung s disease. Cell 1994 79 1257-1266. 

Grantcharova E, Reusch HP, Grossmann S, Eichhorst J, Krell HW, Beyermann M, Rosenthal W, Oksche A. 2006. N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells. Arterioscler Thromb Vase Biol 26 1288-1296. 

M., Ishii, H. Enhanced expression of endothelin B receptor at protein and gene levels in human cirrhotic liver. J. Pathol. 2001 159 1353-1362... 

Despite short-term benefits of bosentan in systemic hypertension and congestive heart failure, it increases plasma concentrations of endothelin-1, probably by inhibiting its clearance via endothelin-B receptors. This may mean that its effectiveness is reduced during long-term therapy (7). 

High salt diet in rats The reduced vasoconstrictor response of the afferent arteriole to endothelin durining a high salt diet is mediated by endothelial endothelin (B) receptors [231]... 

Ge Y, Bagnall A, Stricklett PK, Strait K, Webb DJ, Kotelevtsev Y, Kohan DE Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. American Journal of Physiology - Renal Physiology 291 F1274-F1280, 2006... 

Yamaguchi T, Murata Y, Fujiyoshi Y, Doi T. Regulated interaction of endothelin B receptor with caveolin-1. Eur J Biochem 2003 270 1816-1827. 

Alanen, K., D. X. Deng, and S. Chakrabarti. 2000. Augmented expression of endothelin-1, endothelin-3 and the endothelin-B receptor in breast carcinoma. Histopathology 36 161-167. 

Forbes JM, Jandeleit-Dahm K, Allen TJ, Hewitson TD, Becker GJ, Jones CL Endothelin and endothelin b receptors are increased after ischaemic acute renal failure. Exp Nephrol 9 309-16, 2001... 

Masereeuw R, Terlouw SA, van Aubel RA, Russel FG, Miller DS. Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule. Mol Pharmacol 2000 57(1) 59-67. 

Haug C, Schmid-Kotsas A, Zom U, et al. Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and mono-... 

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