Endoplasmic reticulum-associated degradation pathway

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The Ubiquitin-Proteasome Pathway and Endoplasmic Reticulum-Associated Degradation... 

Embden-Meyerhof-Parnas pathway 650 photobioreactors 589,628 endoplasmic reticulum (ER) 648, 701 endoplasmic reticulum associated degradation (ERAD) 701 enzymes 677,703... 

Dtirr G, Strajde J, Plemper R, Elbs S, Klee SK, Catty P, Wolf DH, Rudolph HK (1998) The medial-Golgi ion pump Pmrl supplies the yeast secretory pathway with Ca2-f- and Mn2+ required for glycosylation, sorting, and endoplasmic reticulum-associated protein degradation. Mol Biol Cell 9 1149-1162... 

Hazes B and Read RJ (1997). Accumulating evidence suggests that several AB-toxins subvert the endoplasmic reticulum-associated protein degradation pathway to enter target cells. Biochemistry, 36, 11051-11054. 

Mancini R, Aebi M, Helenius A. (2003) Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells. J Biol Chem 278(47), 46895M6905. 

Simpson, J.C., Roberts, L.M., Romisch, K., et al., 1999. Ricin a chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast. FEBS Lett. 459 (1), 80-84. Oct 1, 1999. 

Chaperones. Figure 2 The multiple roles of BiP in the biogenesis of the secretory proteins. BiP, immunoglobulin heavy chain binding protein ER, endoplasmic reticulum ERAD, ER-associated degradation ERj, resident ER protein with J-domain Sec61, core subunit of the protein translocase UPR, unfolded protein response that involves several signal transduction pathways that are activated in order to increase the biosynthetic capacity and decrease the biosynthetic burden of the ER... 

Ramos-Castaneda, J., Park, Y.N., Liu, M., Hauser, K., Rudolph, H., Shull, G.E., Jonkman, M.F., Mori, K., Ikeda, S., Ogawa, H., and Arvan, P., 2005, Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress. J. Biol. Chem. 280, 9467—9473... 

Fig. 3. Synthesis, secretion, and transport of lipoprotein lipase (LPL) from the adipocyte to the vascular endothelial surface of adipose tissue. Degradative pathways from the Golgi compartment and cell surface are illustrated. ER, endoplasmic reticulum RAP, receptor-associated protein LRP, LDL receptor-related protein.

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