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Endoperoxides antitumour activities

Peroxy derivatives of steroids have been isolated from both marine and terrestrial sources. They are most commonly 5a, 8a-endoperoxides with variations in the side-chains. The ergosterol peroxide 102 is the most ubiquitous endoperoxide-containing natural product and is isolated from a large number of sources. Ergosterol peroxide 102 was found to have antitumour activity against breast cancer and carcinosarcoma cell lines. A number of other steroidal endoperoxides have been reported which differ in the nature of the side-chain. Compound 103 was found to be an inhibitor of tumour promotion in mouse studies . [Pg.1334]

Antiproliferative trioxane dimers, 283 Antitumour active trioxane dimers, 283 Antitumour endoperoxides, 1333-41 AN02, 1335... [Pg.1443]

See other pages where Endoperoxides antitumour activities is mentioned: [Pg.1490]    [Pg.1490]    [Pg.1280]    [Pg.1335]    [Pg.1335]    [Pg.1338]    [Pg.1280]    [Pg.1335]    [Pg.1335]    [Pg.63]    [Pg.1281]    [Pg.1281]    [Pg.1338]    [Pg.381]   


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Antitumour

Antitumour activity

Antitumour endoperoxides

Endoperoxidation

Endoperoxide

Endoperoxides/endoperoxidation

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