Antitumour endoperoxides

Biomimetic Fe(ll) chemistry and synthetic studies on antimaiarial and antitumour endoperoxides... [Pg.1279]

Antiproliferative trioxane dimers, 283 Antitumour active trioxane dimers, 283 Antitumour endoperoxides, 1333-41 AN02, 1335... [Pg.1443]

CIO carba dimers, antitumour endoperoxides, 1337, 1340 Cage stmcture... [Pg.1447]

VIII. ENDOPEROXIDE CONTAINING COMPOUNDS WITH ANTITUMOUR... [Pg.1333]

Peroxy derivatives of steroids have been isolated from both marine and terrestrial sources. They are most commonly 5a, 8a-endoperoxides with variations in the side-chains. The ergosterol peroxide 102 is the most ubiquitous endoperoxide-containing natural product and is isolated from a large number of sources. Ergosterol peroxide 102 was found to have antitumour activity against breast cancer and carcinosarcoma cell lines. A number of other steroidal endoperoxides have been reported which differ in the nature of the side-chain. Compound 103 was found to be an inhibitor of tumour promotion in mouse studies . [Pg.1334]

In the final part of this chapter, we will look at studies where endoperoxides have been investigated for their antitumour potential. There have been a large number of endoperoxide-containing natural products isolated and this has been the focus of some excellent review articles. Countless peroxy natural products have been assayed for various biological properties and many have been found to be cytotoxic to tumour cell lines. [Pg.1333]

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