Endomyces reessii

Hydroxylation of short chain aliphatic carboxylic acids can be accomplished by a number of micro-organisms (see also Scheme 3) including Endomyces reessii, Trichosporum fermentans, Torulopsis Candida and Micrococcusflavus. Longer chain carboxylic acids can also be satisfactorily hytfaoxylat ... 

Apart from acetone-dried G. candidum IFO 4597, intact whole cells of various strains of G. candidum have been found to be useful for asymmetric reduc-tions(75 78, 101, 120 167 171) For example, methyl 2-acetylbenzoate was reduced by G. candidum ATCC 34614, IFO 5767 or IFO 4597 as well as by other microorganisms such as Mucor javanicus, Mucor heimalis, Endomyces magnusii, Endomyces reessii and bakers yeast to afford phthalide derivatives (Fig. 15-26) which have various pharmacological profiles such as relaxant, antiproliferative or antiplatelet effects, etc.[171). 

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