Endogenous protein images

Giepmans, B. N., Deerinck, T. J., Smarr, B. L., Jones, Y. Z., and Ellisman, M. H. (2005) Correlated light and electron microscopy imaging of multiple endogenous proteins using quantum dots. Nat. Methods 2, 742-749. 

The activity of MMPs is subject to complex regulation, involving both transcriptional and posttranslational mechanisms. The latter involves a group of endogenous protein inhibitors known as tissue inhibitors of metaUoproteinases (TlMPs), of which there are several. The balance of these enzymes is a major determinant of extracellular matrix control (58). TIMPs have been radiolabeled for imaging studies but have not yet been validated in vivo (59). 

Campagnola, P. J., Millard, A. C., Terasaki, M., Hoppe, P. E., Malone, C. J., and Mohler, W. A. 2002. Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues. Biophys. J. 82 493-508. 

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