Endocytic index

Polymers (1a), (1b), (1d), (3a), (4a) and (5) were tested. Fi gure 3 shows the Endocytic Index (28) measured. The DIVEMA derivatives (1a), (3a) and (4a) Tfave no significant effect on the pinocytosis of 25j pyp (they do not influence the rate of formation of pinocytic vesicles). Polymer (1d) shows marked inhibition of pinocytosis at the highest dose.(This latter finding in vitro corresponds to in vivo results of Breslow et aTi (29)). They found that the removal of colloidal carbon from the blood of test animals is inhibited by high molecular weight DIVEMA). 

Figure 3. Stimulation of endocytosis by D1VEMA and DIVEMA derivatives. Endocytic index in the macrophage test system and ml-PVP used as standard substance.

---