Endocrine-disrupting compounds bioassays

The development of new tests and bioassays is likely to lengthen the list of endocrine disrupters. Recent research on hormonal disruption has not only investigated estrogens and androgens as agonists and antagonists but also considered the development of the individual and the presence of compounds that interfere in other hormonal systems, such as the thyroid system. 

Endocrine disrupters (e.g., bisphenol A) are supposed to be the pollutants in our environment and pose a serious concern in human health. The minute amount of these compounds in our environment is difficult to detect mainly due to lack of a simple and sensitive bioassay method. In the present study, the estrogenic and repellent activities of known estrogenic compounds revealed to be correlated. The particle bioassay method is very simple and... 

In order to identify compounds responsible for specific effects (i.e., endocrine disrupting or AhR hgands) observed in field studies, TIE or bioassay directed analysis approaches have increasingly been apphed over the last decade. In such approaches, sensitive bioassays are used to direct the fractionation of a sample extract until its complexity is sufficiently reduced to enable identification of those compoimds responsible for the activity measured in the bioassay. This strategy is based on differential extraction and fractionation methods and identification by chemical and biochemical analysis. TIE is a well-established technique having been originally developed by... 

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