Endocannabinoid Role in Emotional Reactivity and Mood Tone

Endocannabinoid Role in Emotional Reactivity and Mood Tone [Pg.60]

G-protein a-subunits, opening of K+ channels, membrane hyperpolarization, and consequent fall of Ca2+ entry that, in turn, decreases glutamate release. Similar mechanisms underlie cannabinoid-mediated inhibition of neurotransmitter release in other brain regions, such as the striatum (Gerdeman and Lovinger, 2001 Huang et ai, 2001), the nucleus accumbens (Robbe et al., 2001) and lateral amygdala (Azad et al., 2003). [Pg.61]

This peculiar cellular mechanism has a wide range of functional consequences, such as those on memory, cognition, pain perception, motor behavior, and emotional states. Several lines of evidence support the hypothesis of an important role of cannabinoid modulation in anxiety. [Pg.61]

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