Enclomiphene

Clomiphene may be separated into its E and Z isomers, enclomiphene and zuclomiphene. 

Tamoxifen Variants The earliest triphenylethylene identified as an ER modulator is clomiphene (Clomid ) and was identified by Merrell in 1958. The compound was intended to be used as a contraceptive, based on its contraceptive activity in rat. However, it behaved exactly the opposite in woman, inducing ovulation and improving subfertility. The compound was therefore marketed as a therapy for infertility. The commercial preparation consists of a mixture of enclomiphene and zuclomi-phene, the latter acting as an agonist. Yet, even 50 years after it discovery, clomiphene... 

Structures of the txans-isomer of tamoxifen, raloxifene, tians-clomiphene (enclomiphene), andful-... 

Hepatic metabolism of tamoxifen produces N-desmethyltamoxifen, which has affinity for ER comparable to that of tamoxifen, and lesser amounts of the highly active metabolites 4-hydroxytamoxifen and endoxifen, which have 25-50 times higher affinity for both ERa and ERfi. Raloxifene is a nonsteroidal, polyhydroxylated conpound. Clomiphene has two isomers zuclomiphene (cis-clomiphene), a weak estrogen agonist, and enclomiphene (tcans-clomiphene), a potent antagonist. Fulvestrant is a 7a-alkylamide derivative of estradiol. 

The fertility drug clomiphene (trade name Clomid) is sold as a mixture of diastereomers, enclomiphene and zuclomiphene. Designate each alkene as an or Z isomer. What is wrong with the statement, Clomid is a mixture of two isomers, 30% cis and the remainder trans ... 

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