Encephalomyocarditis virus variant

GLVII, a mouse encephalomyocarditis virus, is restricted in HeLa cells. Both viral yield and viral RNA synthesis are reduced in infected restricted cells. However, the restriction in viral yield is more than ten-fold greater than the restriction of viral RNA synthesis. This observation that the viral yield is more severely depressed than the yield of viral RNA was also seen in the mengoviirus-MDBK system (20). A non-restrictive variant of GDVII was obtained following alternate viral passage on restrictive and permissive hosts. The authors were unable to identify a mechanism of restriction (19) ... 

Effect of Tetramisole and Its Platinum Polyamine on Mice Infected With Encephalomyocarditis-Variant-D Virus 223... 

EFFECT OF TETRAMISOLE AND ITS PLATINUM POLTAMINE ON MICE INFECTED ITH ENCEPHALOMYOCARDITIS-VARIANT-D VIRUS... 

Warchalowski and Strausser found that Levamisole enhanced the diabetogenesis of EMC virus in DBA/2 mice this effect of levamisole was attributed to its action upon T suppressor (Ts) lymphocytes. 2 Mastur-bara et. al. found that levamisole induction of interferon (IFN) in mice was thymus-dependent.2 Also, no induction of IFN was detected in thymus-defective nude mice.2 Nude mice are not susceptible to diabetes mediated by the encephalomyocarditis (EMC) virus. Using the purified diabetogenic D variant of the EMC virus, (EMC-D), Gould et. al. noted that when IFN or low doses of IFN or the interferon inducer, poly(I C) was given 4 days after initiation of EMC-D infection in male ICR Swiss mice, the severity and incidence of virus-induced diabetes melitis was increased. ... 

---