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Enantiotopic groups, definition

The general subject of asymmetric synthesis has been reviewed extensively (1-5). The term asymmetric synthesis has been defined in more than one way (1,4) however, a useful definition is the one given by Morrison and Mosher (1) a process which converts a prochiral unit [refs. 6 and 7] into a chiral unit so that unequal amounts of stereoisomeric products result. The stereoisomeric products may be enantiomeric or they may be diastereomeric. The substrate molecule must contain either enantiotopic or diastereotopic groups or faces (8,9), since the attack of a reagent at equivalent groups or faces cannot lead to isomeric products. [Pg.232]

In retrospect, it seems unfortunate that in 1971 Morrison and Mosher8 generalized the definition, while keeping the term, an asymmetric synthesis is a reaction in which an achiral unit in an ensemble of substrate molecules is converted by a reactant into a chiral unit in such a manner that the stereoisomeric products arc produced in unequal amounts ( Footnote The substrate molecule must have either enantiotopic or diastereotopic groups or faces) . Obviously the phrase "an achiral unit in an ensemble of substrate molecules is too inexact and requires a great deal of additional explanation, which was partially given by the footnote (note that molecule, i.e., singular, was used ). Currently, the Morrison-Mosher term appears to be equivalent to stereoselective reaction. Unfortunately, this term was only defined in the modem sense by Izumi in 1971, i.e., in the same year the Morrison-Mosher definition was published. [Pg.45]

Enantiotopic atoms or groups 479 Endergonic reactions 286 Endo ring conformation 212 Endocytosis 13,425-427 Endoderm 23 Endoglucanases 602 Endoglycanases 593, 602 Endonexin SeeAnnexin Endoplasmic reticulum (ER) 10,13,14, 521 cisternae of 14 definition of 14 in micrograph 13 rough 14 smooth 14 Endosomes 13, 426 Endosperm 30... [Pg.915]

Now, does this ring any bells It should remind you very much of the definitions in Chapter 32 of H enantiotopic and diastereotopic in connection with NMR spectra. Replacing one of two enantiotopic Enantiotopic and diastereotopic groups with another group leads to one of two enantiomers replacing one of two diastereotopic chapter 32 pr<837 dl9CU9sed in... [Pg.885]


See other pages where Enantiotopic groups, definition is mentioned: [Pg.567]    [Pg.885]    [Pg.885]    [Pg.885]    [Pg.856]    [Pg.228]    [Pg.94]    [Pg.140]    [Pg.141]    [Pg.242]    [Pg.158]   
See also in sourсe #XX -- [ Pg.888 ]

See also in sourсe #XX -- [ Pg.5 , Pg.6 , Pg.7 ]




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