Enantiorecognition range

Armstrong et al. ° first introduced chiral stationary phases based on macrocyclic antibiotics. Vancomycin, ristocetin A, teicoplanin, avoparcin, rifamycin B and thiostrepton are used as chiral selectors. They posses a broad enantiorecognition range, similar to protein based CSPs. However, CSPs based on macrocyclic antibiotics show higher stability and capacities.Underivatized amino acids, N-derivatized amino-acids, acidic compounds, neutrals, amides, esters and amines can be separated.The first four of the above-mentioned chiral selectors appear to have the largest enantiorecognition range.The selectors can also be derivatized to obtain different enantioselectivities. 

These polysaccharide-based stationary phases appear to be the most useful in organic, bio-organic and pharmaceutical analysis. Of the above-mentioned derivatives three of them, namely cellulose tris-(3,5-dimethylphenylcarbamate), amylose tris-(3,5-dimethylphenylcarbamate) and cellulose tris-(4-methylbenzoate), have very complementary properties and numerous publications have demonstrated that they have been able to achieve the chiral resolution of more than 80% of the drugs currently available on the market. " These CSPs are known under the commercial names, Chiralcel OD-H , Chiralpak AD and Chiralcel OJ , respectively (Figure 4). Their very broad enantiorecognition range is also the... 

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