Emsam Patch

MAOIs had been reserved as a last line of treatment, used only when other classes of antidepressant drugs had failed, because of the mentioned potentially lethal dietary and drug interactions. However, in 2006 a patch form of the drug selegiline, called Emsam, was approved for use by the FDA. When applied transdermally the drug does... 

Early antidepressant medications were called tricyclic antidepressants (TCA), exemplified by dothiepin and amitriptyline. However, there are toxicity issues with these medications. The next generation of antidepressants was the monoamine oxidase inhibitors (MAOIs). As their name implies, they inhibit the monoamine oxidase enzyme thereby inhibiting the oxidation of monoamines such as serotonin that act as neurotransmitters. Examples include selegiline (available in transdermal patch form as Emsam , Somerset... 

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