Emodin-8-O-p-D-glucoside

Yeh et al. [10] tested chrysophanic acid, emodin (5), physcion (6), emodin-8-0-(3- D-glucoside (7), physcion-8-O-P-Dglucoside (8), and trans-piceid (16) on HL-60 cells to determine their cytotoxic effects. The cells were exposed to known concentrations of the compounds for 72 hours and, using the trypan blue exclusion method, the viable cells were counted. As revealed in Table 2, the results indicate that emodin is the most cytotoxic compound tested. The observed potency is in the order emodin > physcion-8-0- 3-D- glucoside > fraras-piceid > physcion > emodin-8-0- 3-D-glucoside > chysophanic acid. 

---