Emcompress® tablets

J.L. Vila-Jato, A. Concheiro and D. Tones, Influence of storage conditions on the characteristics of digoxin-Emcompress tablets, S.T.P. Pharma, 1 (1985) 194. 

Tablet composition 2.5% disintegrant, 1% magnesium stearate, and Emcompress.

Avicel PH 102 81 Emcompress 213 Mannogem EZ 1.17 Direct Tableting lactose 0.4 Avicel PH 102 0.14... 

Fast Flo lactose 106 Direct Tableting lactose 387 Fast Flo lactose 2.62 Emcompress 0.5 Direct Tableting lactose 0.26... 

Note-. The solid fraction of DCP tableting indices compacts was less than 0.85, particularly for the Emcompress , CD Anhydrous and A-TAB grades . Abbreviation-. DCP, dicalcium phosphate. 

To test the foregoing dimensionless relationship, two powders (Avicel Pl 1101, a ductile, viscoelastic material, and Emcompress, a brittle material, blended with 0.5% magnesium steaiate) were compressed on the PressterTw, a single-station mechanical replicator of rotary tablet presses. In the first set of experiments, a 16-station Manesty Betapress (a research-scale press) was simulated at two speeds, 60 and 100 rpm. In the second set, a 36-station Fette P2090 (a medium-scale production press) was simulated at two speeds, 55.8 and 70 rpm. It should be noted that 100 rpm of the Beta-press corresponds to 55.8 rpm of the Fette 2090 in terms of the linear speed of the turret. Basic parameters for the two tablet presses arc presented in Table 3. 

FIGURE 23 The effect of MgSt admixture on net work (filled symbols) and expansion work (open symbols) in the tabletting of Emcompress and Sta-Rx 1500. ( ) pure substance (A) 0.5% MgSt blended for 1 minute ( ) 0.5% MgSt admixed for 30 minutes. Source Adapted from Ref. 62. 

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