ELR+ CXC chemokines

Addison CL, Daniel TO, Burdick MD, et al. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 2000 165 5269-5277. 

The CXC chemokines can be divided into two groups on the basis of a structure/function domain consisting of the presence or absence of three amino acid residues (Glu-Leu-Arg ELR motif) that precedes the first cysteine amino acid residue in the primary structure of these cytokines. The ELR+ CXC chemokines are chemoattractants for neutrophils and act as potent angiogenic factors (6). In contrast, the ELR" CXC chemokines are chemoattractants for mononuclear cells and are potent inhibitors of angiogenesis (Table 1) (6). 

CXCR2 Is the Receptor for Angiogenic ELR+ CXC Chemokine-Mediated Angiogenesis... 

Goldberg-Bittman L, Sagi-Assif O, Meshel T, et al. Cellular characteristics of neuroblastoma cells regulation by the ELR -CXC chemokine CXCL10 and expression of a CXCR3-like receptor. Cytokine 2005 29 105-117. 

Fig. 1 Model of erythrocyte DARC function in the prostate cancer microenvironment. Expression of erythrocyte DARC binds and clears angiogenic ELR+CXC chemokines from the tumor. However, lack of the erythrocyte DARC results in a higher than normal intratumor concentration of angiogenic chemokines...

During malignant transformation of prostate epithelial cells, reprogramming of the transcriptional machinery occurs and these cells begin to produce high amounts of ELR + CXC chemokines. These chemokines bind to their receptor, CXCR2, on vascular endothelial cells and promote neovascular formation by... 

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