Calcium elenolate

Mono Diterpenes A -Tetrahydrocannabinoi (159), Calcium elenolate, Scopadulcic acid B (160), Scopadulin... 

Renis, H.E. In Vitro Antiviral Activity of Calcium Elenolate. Antimicrob. Agents Chemother. 1969,0, 167-172. 

Two compounds are of considerable interest in this group, 3-ethoxy-2-oxobutanal hydrate (Kethoxal, LXV) and calcium elenolate (LXVI). 

Calcium elenolate (LXVI) whose structure has just been revised from an open chain aliphatic dialdehyde is also a wide spectrum extracellular virus inactivator, as might possibly be expected from comparison of its structure with that of Kethoxal. The acid is obtained from extracts of olive plants and its calcium salt has a minimal effective concentration of 0-75 per cent when tested intranasally in hamsters infected with parainfluenza 3. This concentration applied six times in 28 hours had no toxic effects and aborted the virus infection. A concentration of 0-6 per cent tested intranasally in rabbits over an extended period produced mild to moderate changes in the nasal epithelium, but a 1 0 per cent nasal spray four times daily for 14 days was well tolerated in humans [245-247]. 

---