Electrospray interface diagram

Figure 4.1 A schematic diagram of a microdevice with subatmospheric electrospray interface. The expanded view shows the coupling of the ESI tip with the separation channel in the liquid junction [13].

Figure 9.11. Schematic diagram of (a) sheathless, (b) sheath-flow and (c) liquid-junction electrospray interfaces for CE-MS. (From ref. [84] Elsevier).

Figure 9.12 Schematic diagram of the silica sheath electrospray needle used to interface capillary zone electi ophoresis with a mass spectrometer.

The interfaces that effectively replaced the transport system were the thermospray and electrospray sample introduction systems. The thermospray interface, a diagram of which is shown in figure 23, is a development from the direct inlet system of McLafferty. The successful use of the thermospray interface was first reported by... 

Figure 4.11. Schematic diagram of an LC/MS electrospray ionization (ESI) interface showing the nebulization of the LC eluent into droplets, evaporation of the solvent, and the ionization of the analytes, which are pulled inside the MS. Diagram courtesy of Agilent Corporation.

Mass spectrometry with its excellent sensitivity is emerging as one of the most powerful analytical techniques.16 Its importance was recognized by the awarding of the 2002 Nobel Prize in Chemistry to John B. Fenn and Koichi Tanaka for their research in mass spectrometric methods for biomolecules. The primary difficulties of combining LC and MS have been the interface, and the ionization of analytes in a stream of condensed liquids and transfer of ions into the high vacuum inside the mass spectrometry. Two common LC/MS interfaces are the electrospray ionization (ESI) and the atmospheric pressure chemical ionization (APCI). Figure 4.13a shows a schematic diagram of an... 

Figure 9.10. Schematic diagram of a packed column SFC-MS interface with electrospray ionization. This interface features a liquid pressure-regulating flow for pressure control to just before the expansion region. (From ref. [75] Elsevier).

Figure 13.16 Diagram of orthogonal electrospray LC-MS interface. (Adapted with permission...

Figure 13.19 Diagram of orthogonal electrospray LC-MS interface. (Courtesy of Agiient Technoiogies, Santa Clara, CA, www.agllent.com/chem. With permission.)...

FIGURE 10 Diagram of the Bruker orthogonal electrospray LC/MS interface. [Reprinted by permission from the Bruker-HP Esquire LC Operations Manual, Version 3.1.)... 

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