Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Electron-donating groups substitution

Interestingly, when olefin 301 with a strong electron-donating group substituted on the phenyl ring of the double bond was employed in the reaction, a reversed regi-oselectivity was observed and product 302 obtained (Scheme 3.82). [Pg.210]

An experimental and theoretical investigation of electronic effects in ruthenium catalyzed cycloadditions with internal diarylalkynes has shown that 5-electron-donating group substituted triazoles should be favored [155]. This effect was further observed in the synthesis of 5-amino-triazoles from ynamides (Scheme 65) [156]. [Pg.226]

A tertiary carbonium ion is more stable than a secondary carbonium ion, which is in turn more stable than a primary carbonium ion. Therefore, the alkylation of ben2ene with isobutylene is much easier than is alkylation with ethylene. The reactivity of substituted aromatics for electrophilic substitution is affected by the inductive and resonance effects of a substituent. An electron-donating group, such as the hydroxyl and methyl groups, activates the alkylation and an electron-withdrawing group, such as chloride, deactivates it. [Pg.48]

The 3-, 4-, 5- and 6-positions in the pyridazine nucleus are electron deficient due to the negative mesomeric effect of the nitrogen atoms. Therefore, electrophilic substitution in pyridazines is difficult even in the presence of one or two electron-donating groups. The first reported example is nitration of 4-amino-3,6-dimethoxypyridazine to yield the corresponding 5-nitro derivative. Nitration of 3-methoxy-5-methylpyridazine gives the 6-nitro-,... [Pg.20]

Reaction 12, the acid-catalyzed hydrolysis of substituted benzamides, has p = — 0.22, so the reaction is modestly facilitated by electron-donating groups. This suggests that protonation of the amide is kinetically important ... [Pg.330]

The electronic properties of the aniline are important in the Doebner reaction. The reaction works best with electronic donating groups. Anilines substituted with a chlorine at the meta position consistently give low yields, but fluorine at the meta position seems... [Pg.409]

As previously described, the Gould-Jacobs reaction has been applied to heterocycles fused to anilines, and to some amino-substituted heterocycles. Selectivity of N- and C-cyclization of 2-aminopyridino-methylene malonates has been mentioned (51 and 56). The normal mode of cyclization of 2-aminopyridino-methylene malonates is on the nitrogen to form a pyridopyrimidine. If an electron-donating group (EDG) is in the 6-... [Pg.432]

Fig. 8.16 The different approaches of an alkene substituted with an electron-donating group (EDG) to nitroethene... Fig. 8.16 The different approaches of an alkene substituted with an electron-donating group (EDG) to nitroethene...
Activating group (Section 16.4) An electron-donating group such as hydroxyl (-OH) or amino (— NH2) that increases the reactivity of an aromatic ring toward electrophilic aromatic substitution. [Pg.1234]


See other pages where Electron-donating groups substitution is mentioned: [Pg.153]    [Pg.458]    [Pg.222]    [Pg.219]    [Pg.63]    [Pg.112]    [Pg.153]    [Pg.458]    [Pg.222]    [Pg.219]    [Pg.63]    [Pg.112]    [Pg.75]    [Pg.77]    [Pg.136]    [Pg.33]    [Pg.710]    [Pg.746]    [Pg.426]    [Pg.390]    [Pg.426]    [Pg.42]    [Pg.292]    [Pg.299]    [Pg.86]    [Pg.50]    [Pg.81]    [Pg.35]    [Pg.123]    [Pg.326]    [Pg.381]    [Pg.89]    [Pg.165]    [Pg.230]    [Pg.221]    [Pg.263]    [Pg.289]    [Pg.4]    [Pg.175]    [Pg.59]    [Pg.637]    [Pg.760]    [Pg.774]    [Pg.142]    [Pg.9]    [Pg.20]    [Pg.276]   
See also in sourсe #XX -- [ Pg.344 , Pg.508 , Pg.509 , Pg.510 , Pg.518 , Pg.578 , Pg.649 ]




SEARCH



Electron donation

Electron-donating group

Electrons substitution

Substituted benzenes groups that donate electrons

© 2024 chempedia.info