Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Electron-affinic drugs

Drug-receptor interactions often involve CT complex formation. Examples include the reactions of antimalarials with their receptors and of some antibiotics that intercalate with DNA. The CT energy is proportional to the ionization potential of the donor and the electron affinity of the receptor, but is usually no higher than about 30 kJ/mol. [Pg.73]

The latter value is most appropriate for comparing the relative electron affinities of oxygen and drugs in aqueous solutions. This property is reflected in the position of the equilibrium, equation (4), which is a general example of redox equilibria involving one-electron transfer (5) ... [Pg.627]

We have also determined the delivery sites of alkylbenzenes by NMR. As already described in Section III.A, PrBe are deeply transported to the chain tail region in the bilayer core and the delivery site can be classified into category III [46]. Benzene, however, cannot deeply penetrate into the hydrophobic core, zone III, but is trapped preferentially at the interfacial site of the bilayer, zone II the delivery site can be classified into category II. Although benzene is generally considered to be hydrophobic, the delivery site of benzene determined by NMR is reasonable in the sense of the 7r-electrons with some affinity for the hydrophilic sites of the bilayer. Both drug and lipid sides of the H NMR spectra show that alkylbenzenes can deeply penetrate into the bilayer interior in the order PrBe > ethylbenzene > toluene > benzene, which is consistent with the sequence of the insolubility in water. [Pg.797]

The drug interferes with the mitochondrial electron transport chain. It seems that this is due to a high affinity of the drug for lipids such as cardiolipin, a component of the mitochondrial inner membrane. It therefore accumulates there. [Pg.344]

Second-derivative electronic absorption spectrophotometry, which is a method applied without any separation procedure, was used to determine the partition coefficients of three N-monodemethylated phenothiazine drugs, such as CPZ, triflupromazine and promazine, between the phosphatidylcholine bilayers of small unilamellar vesicles (SUVs) and water, in order to evaluate their affinity to biomembranes. The second-derivative spectra exhibited distinct isobestic points, confirming the entire elimination of the residual background signal effects of the SUVs which were observed in the conventional absorption spectra [161]. [Pg.210]

The concept of structural similarity to the transition state has found wide application in drug design over the years. The multitude of enzyme-inhibitor interactions are governed by steric as well as electronic factors. In theory, compounds that closely resemble the transition state structure should give high binding affinity towards the target enzyme. [Pg.130]


See other pages where Electron-affinic drugs is mentioned: [Pg.243]    [Pg.243]    [Pg.411]    [Pg.256]    [Pg.296]    [Pg.727]    [Pg.616]    [Pg.175]    [Pg.608]    [Pg.62]    [Pg.55]    [Pg.76]    [Pg.944]    [Pg.96]    [Pg.144]    [Pg.134]    [Pg.253]    [Pg.67]    [Pg.181]    [Pg.223]    [Pg.73]    [Pg.340]    [Pg.181]    [Pg.217]    [Pg.172]    [Pg.37]    [Pg.1191]    [Pg.1936]    [Pg.31]    [Pg.700]    [Pg.117]    [Pg.212]    [Pg.19]    [Pg.128]    [Pg.32]    [Pg.209]    [Pg.965]    [Pg.770]    [Pg.1808]   
See also in sourсe #XX -- [ Pg.5 , Pg.180 , Pg.181 , Pg.182 ]




SEARCH



Drug affinity

Electron affinity

Electronic affinity

Electrons electron affinity

© 2024 chempedia.info