Electroenzymatic synthesis

The results presented here demonstrate the first successful applications of the concept of electroenzymatic synthesis. However, it is also obvious that many more systems are potentially very interesting for synthetic applications. This area is wide open for further creative research and only the tip of the iceberg has surfaced. What is especially promising is the fact that electroenzymatic synthesis is an environmentally friendly technique using the electrode as a clean reagent and the enzymes for high selectivity. Closed systems for technical applications are easier to realize than in many other areas. The author is convinced that industrial syntheses of valued small scale products will be seen in the near future. 

AJ Fry, SB Sobolov, MD Leonida, KI Voivodov, J Fenton. New biopolymers for electroenzymatic synthesis of a-hydroxy acids. Electrochem Soc Proc 97 115-122, 1997. 

The preparative aspects of organic electrochemistry are presented in the fundamental review by Lund and Baizer.4 An earlier review5 includes the technical aspects of electroorganic synthesis. Indirect methods in preparative organic electrochemistry also have been summarized 6 these methods are used in the production of fine chemicals and pharmaceuticals. Electroenzymatic synthesis also has been reviewed.7... 

Kohlmann C, Maerkle W, Liitz S (2008) Electroenzymatic synthesis. J Mol Catal B Enzym 51 57-72... 

Hildebrand F, Liitz S (2007) Electroenzymatic synthesis of chiral alcohols in an aqueous -organic two-phase system. Tetrahedron Asymmetry 18 1187-1193... 

Steckhan, E., Arns, Th., Heinemann, W.R., Hilt, G., Hoormann, D., Kroner, L., Lewall, B. and PUtter, H. (2001) Environmental protection and economization of resources by electroorganic and electroenzymatic synthesis. Chemosphere 43, 63-73. 

Fig. 24 Electroenzymatic synthesis of L-lactate coupled with cofactor regeneration using a FAD-modified electrode...

The first example of an asymmetric electroenzymatic synthesis with a peroxidase was carried out with thioanisole and chloroperoxidase from Caldariomyces fumago. 

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