Ehrlich-Sachs reaction

Aromatic nitroso compounds are able to condense with numerous compounds containing reactive methylene groups this, the Ehrlich-Sachs reaction,430 affords Schiff bases, whence the corresponding carbonyl compound and amine can be obtained by hydrolysis [Pg.447]

The methylene component may be provided by / -dicarbonyl compounds, phenyl- or cyano-acetic ester derivatives, nitrotoluenes, the methiodide of 1- or 3-picoline, etc.430-435 (cf. page 424). [Pg.447]

It is best to use an alkaline condensing agent such as an alkali hydroxide, sodium carbonate, pyridine, or an alkoxide. [Pg.447]

4-Dinitrobenzylidene)-p-(diethylamino)aniline 204 2,4-Dinitrotoluene (91 g) and N,N-diethyl-p-nitrosoaniline (90 g) are dissolved in ethanol (ca. 500 ml) and heated under reflux for 5 h with crystalline sodium carbonate (150 g). After cooling, the product is filtered off and [Pg.447]

In some cases the condensation is such a violent reaction that it is preferable to mix the reactants portionwise or to add the condensing agent in very small portions. When reaction in an aqueous-alcoholic medium it unsatisfactory, it is better to use an anhydrous alcoholic solution containing an alkoxide.311 [Pg.448]

Keywords active methylene compound, LiBr, nitroso arene, Ehrlich-Sachs reaction, microwave irradiation, imine... [Pg.293]

Although reactions with N=0 derivatives do not formally fall into this category of reactions, it is somewhat related. Nitroso compounds react with activated nitriles in the presence of LiBr and microwave irradiation to give a cyano imine, ArN=C(CN)Ar. This transformation has been called the Ehrlich-Sachs reaction ... [Pg.1368]

Ehrlich-Sachs reaction. Formation of anils by the base-catalyzed condensation of compounds containing active methylene groups with aromatic ni-troso compounds. [Pg.491]

Other references related to the Ehrlich-Sachs reaction are cited in the literature. ... [Pg.966]

Robinson Annulation Robinson-Schopf Reaction Rosenmund Reduction Rosenmund-von Braun Synthesis Rothemund Reaction Rubottom Oxidation Ruff-Fenton Degradation Rupe Rearrangement Ruzicka Large Ring Synthesis Sabatier-Senderens Reduction Sachs (see Ehrlich-Sachs Reaction)... [Pg.13]

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