EGDMA

Hoffman and his coworkers have done a lot of work on the apphcation of radiation-induced graft polymerization for medical apphcation. The hydrophilic polymers that have been used for radiation-induced grafting are Al-vinyl pyrohdone (NVP), 2-hydroxyethyl methacrylate (HEMA), acrylamide (AAm), acrylic acid (AAc), glycidyl methacrylate (GMA), ethyleneglycol dimethacrylate (EGDMA), and ethyl methacrylate (EMA) onto sihcone rubber were widely smdied. 

Ethylene glycol dimethacrylate EGDMA Elydrophobicity Wettability... 

Table II. Peak time of the Photo-DSC of HEMA monomer mix with different of UV initiators. Formulation HEMA/Glycerine/EGDMA/initiator 85/15/0.34/x...

Table IV. Peak times in the Photo-DSC of HEMA with different diluents at 5, 15 and 25 % Formulation HEMA/EGDMA/BME/Diluent at 85/0.34/0.17...

Table V. Glass Transition temperatures of cured HEMA samples. Formulation HEMA/EGDMA/BME/Diluent 85/0.34/0.17/X...

The Effect of Crosslinker Concentration on the Rate of Polymerization. Ethylene glycol dimethacrylate is used most frequently as the crosslinker for HEMA formulations useful in contact lens manufacturing. To demonstrate the effect of crosslinker concentration on the curing rate, formulations derived from HEMA/Glycerine/BME at 85/15/0.17, while varying EGDMA (from 0.34 to 0.68), the peak times were about the same (3.73 and 3.61 minutes respectively). This is reasonable due to the similarity in molecular structure of the crosslinker and the monomer, and the low amount of crosslinker used. The possible presence of other crosslinker, such as the dimerization product of HEMA, is even less a factor to be considered in polymerization kinetics, due to low concentration (normally much less than 0.1 %, in-house information). 

Table VI. Percentage conversion versus stall time in the Photo-DSC of HEMA-based monomer mixes. Formulation HEMA/EGDMA/Glycerine at 85/0.34/15...

Table VII. The Effect of initiator and initiator concentration on properties of HEMA hydrogels HEMA/Glycerine/EGDMA/Initiator at 85/15/0.34/X...

TM =TMPTMA, EM = EGDMA, DM = DEGDMA, TEM = TEGDMA. PM = PEGDMA. conditions as in footnote a, Table VIII. 

Fig. 10. Representative GC-traces of spiked human plasma samples subjected to either (top) liquid-liquid extraction followed by MI-SPE or (bottom) standard liquid-liquid extraction only. Human plasma was spiked with 66.8 nmol/1 of sameridine and 50.2 nmol/1 of internal standard. A sameridine (Ri = methyl, R2 = ethyl), B internal standard, C imprint species (Rx = methyl, R2 = methyl). MIP was composed of MAA and EGDMA. Reprinted with permission from An-dersson LI (2000) J Chromatogr 739 163. Copyright 2000 Elsevier Science...

Fig. 11. Representative GC-traces of spiked human plasma subjected to (top) MI-SPE and (bottom) SPE with a non-imprinted control polymer. Plasma was spiked with 160 nmol/1 bupivacaine. MIP was composed of MAA and EGDMA and imprinted with pentycaine as a structural analogue to bupivacaine. Reprinted with permission from Andersson LI (2000) Analyst 125 1515. Copyright 2000 The Royal Society of Chemistry...

Fig. 12. Response of the MIP sensor to phenacetin (curve 1), paracetamol (curve 2), antifebrin (curve 3), phenetol (curve 4). The same electrode was used for all detections in a 10-ml sample volume (aqueous system). MIP was composed of MAA and EGDMA and imprinted with phenacetin. Reprinted with permission from Tan Y, Peng H, Liang C, Yao S (2001) Sensors Actuators B 73 179. Copyright 2001 Elsevier Science...

Fig. 14. Application of an AT-benzylisopropylamine imprinted MAA/EGDMA copolymer as catalyst for the dehydrofluorination of 4-fluoro-4-(p-nitrophenyl)-2-butanone in a batch reactor. Given is the substrate concentration versus time. The reaction was carried out at 50° C in 10 ml of a mixture of water and acetonitrile 1 1 (v/v), containing 5 mg of the substrate 4-fluoro-4-(p-nitrophenyl)-2-butanone (i. e., a final concentration of 2.4 mmol/1) and 500 mg MIP or non-im-printed control polymer (CP). Top use of MIP, 1. experiment ( ), 2. experiment ( ). Bottom use of CP, 1. experiment ( ), 2. experiment ( ). Reprinted with permission from Briiggemann O (2001) Anal Chim Acta 435 197. Copyright 2001 Elsevier Science...

Copolymeriziation of polystyrene-bound dicyanoketene acetal (DCKA) and ethylene glycol dimethacrylate (EGDMA) yielded a polymer (41) with high n -acidity. It was found to be an effective and completely recyclable catalyst in the high yielding carbon-carbon bond-forming reaction of dimethylacetals with silylated nucleophiles (Scheme 4.26) [118]. 

Scheme 15.3 Noncovalent imprinting of L-phenylalanine anilide in a methacrylic acid (MAA)/ethylene glycol dimethylcrylate (EGDMA) polymer matrix. Adapted from Sellergren et al. (1998). Copyright 1988 American Chemical Society.

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