Effervescent formulation lubricants

Twenty lubricants for effervescent tablets were tested for lubrication efficiency in direct compression of a standard effervescent formulation. The lubricant concentration was high as compared to traditional tablet lubricants. By increasing the lubricant concentration... 

Rotthauser, B., Kraus, G., and Schmidt, P. C. (1998), Optimization of an effervescent tablet formulations containing spray-dried L-leucine and polyethylene glycol 6000 as lubricants using a central composite design, Eur. J. Pharm. Biopharm., 46, 85-94. 

Roscheisen, G. Schmidt, P.C. Preparation and optimization of L-leucine as lubricant for effervescent tablet formulations. Acta Pharm. Helv. 1995, 70, 133-139. 

Fumaric acid has been investigated as a lubricant for effervescent tablets and copolymers of fumaric acid and sebacic acid have been investigated as bioadhesive micro-spheres. " It has been used in film-coated pellet formulations as an acidifying agent and also to increase drug solubility. ... 

Lubricant substances which are reported in literature as suitable for effervescent manufacturing because they are water soluble are sodium benzoate, sodium acetate, L-leucine, and Carbowax 4000. A very recent application is a combination of calcium and potassium sorbates, micronized polyethylene glycol with calcium ascorbate or trisodium citrate (20). Combination of spray-dried L-leucine and polyethylene glycol 6000 has been reported as a successful lubricant in the literature (21). Other less soluble lubricants have been used in formulating effervescent tablets, however, a balance should be found between compression efficiency and water solubility. Magnesium stearate is also employed but the most suitable, commercially available type is its combination with sodium lauryl sulfate, a surface-active agent that helps in its dispersion (22). 

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