Effect of NO on Protein Expression and Gene Transcription

NO is also able to modulate vascular functions by altering the expression of genes encoding certain endothelial proteins as well as the genes that encode them. These effects underscore the significance of endothelium-derived NO, both in short-term and long-term vascular homeostasis. 

The adhesion of monocytes to the vascular endothelium, followed by their recruitment into the subendothelial space, is one of the earliest events to occur in the pathogenesis of atherosclerosis and leads to the development of the lipid-laden foam cell-containing lesion (for a review see Sanders, 

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