Edit events

Choose this to build and edit-event trees. The Event Tree List dialog appears listing all event trees and subtrees in the current family. A pop-up menu provides the following options ... 

Edit Graphics - constructs and edits event trees using the graphical Event Tree Editor. 

Edit Rules - defines and edits event tree linkage rules using the Linkage Rules Editor. A... 

A landmark paper by Bums and colleagues (115) first described RNA editing events in rat brain. RNA editing involved an adenosine to inosine substitution, required the action of two separable double-stranded RNA (dsRNA) and adensosine deanimase(s) (ADARs), and occurred at four sites (A, B, C, and D) located within the second intracellular loop of the receptor. RNA editing in the r5-HT2C receptor resulted in seven major isoforms (VNV, VSV, VNI, VSI, INV, ISV, and INI) encoded by 11 RNA species (115). Also, patterns of RNA editing were tissue-specific the most common variants (VNV, VSV, VNI, and VSI) were expressed in the whole brain and hippocampus, whereas the least common variants (INV, ISV, and INI) were expressed in the choroid plexus. Functionally,... 

Niswender CM, Sanders-Bush E, Emeson RB. Identification and characterization of RNA editing events within the 5-HT2C receptor. Ann NY Acad Sci 1998 861 38-48. 

RNA editing is a post-transcriptional event that changes one canonical nucleotide into another in nascent RNA transcripts, especially in mRNAs. Since this has the potential to change the amino acid identity of the pertinent codon, RNA editing has been shown to play an extremely important role in generating protein diversity and/or regulating translation specificity. Of all the RNA editing events, deamination is probably the one that has been most extensively studied. In this section, two representative deamination modifications, adenosine to inosine (A to I) and cytidine to uridine (C to U) conversions are discussed. 

A screen as shown in Figure 2 is used for editing event sequences for all the staff involved in the incident. Each row of the boxes in the figure shows the event sequence for a separate member of the related staff. Creation, changing the title, and rearrangement of sequence by drag-and-drop are allowed for each box, which corresponds to a unitary cabin crew task. The reporter enters box titles that represent briefly what happened and arrange them in the order of event occurrence. This operation is repeated to describe all the event sequences. 

An edit history for an individual user is a sequence of timestamped edit events, where an event consists of the title of the article edited and an optional user comment. 

An edit event is a discrete action that is captured and sent to the server as an update request. Eor example, moving a part from... 

Chylomicrons and VLDL carry many apolipoproteins, among them apo-B and apo-E. Apo-B is a large (MW = 516 kDa) protein stably associated with the lipoprotein particle. The intestine produces a truncated form of the apoB, termed apo-B48, which is missing the carboxy-terminal half of apoB. The mechanism for the truncation involves a unique RNA editing event in the intestine that changes a Gin codon (CAA) to a STOP codon (UAA). Since only VLDL is converted to LDL, this means all apo-B in LDL is apo-B 100 (Fig. 7). 

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