Ed man degradation

Eclipsed conformation, 94 molecular model of, 94 Edman, Pehr Victor, 1031 Ed man degradation, 1031-1032 mechanism of. 1032 Eicosanoid, 1067-1070... 

Strategies for the determination of natural T-cell epitopes include mostly the identification of epitopes from source proteins by molecular genetic techniques. Truncation mutants of the original genes were analyzed in bioassays and further characterized with overlapping peptides [29]. Alternatively, natural T-cell epitopes are eluted from cell lines that restrict the T-cell response. The eluted peptides are purified and sequenced by Ed-man degradation [30]. 

USE Derivatizing agent for primary, secondary amines, la sequencing of peptides by Ed man degradation. In amino add analyses by HPLC (Pico-Tag). 

T. J. Ahern, M.C Manning, eds. Stability of protein pharmaceuticals, Part A. Chemical and Physical Pathways of Protein Degradation. New York Plenum Press, 1992. 

S. N. Timasheff, Stabilization of protein structure by solvent additives, in Stability of Protein Pharmaceuticals, Part B In Vivo Pathways of Degradation and Strategies for Protein Stabilization (T. J. Ahern and M. C. Manning, eds.), Plenum Press, New York, 1992, pp. 265-285. 

Groves, M.J. and Teng, C.D. (1992). The effect of compaction and moisture on some physical and biological properties of proteins. In Stability of Protein Pharmaceuticals, Part A Chemical and Physical Pathways of Protein Degradation, T.J. Ahem and M.C. Manning, eds. Plenum Press, New York, 311-359. 

Guthrie JT, Mannings CS (1990) The cellulose/N-methylmorpholine-N-oxide/F O system degradation aspects. In Kennedy JF, Phillips GO, Williams PA (eds) Cellulose sources and exploitation. Ellis Horwood Ltd., Chichester, p 49... 

Millward DJ, Bates PC, Brown JG, Rosochacki SR, Rennie MJ (1980) Protein degradation and the regulation of protein balance in muscle. Excerpta Medica 75 307-329 Millward DJ, Brown JG, Odedra G (1981) Protein turnover in individual tissues with special emphasis on muscle. In Waterlow JC, Stephen JML (eds) Nitrogen metabolism in man. Appl Sci Publ, London... 

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