Eczema, allergic drug reaction

Sinus problems, hay fever, bronchial asthma, hives, eczema, contact dermatitis, food allergies, and reactions to drugs are all allergic reactions associated with the release of histamine and other autocoids, such as serotonin, leukotrienes, and prostaglandins. Histamine release is frequently associated with various inflammatory states and may be increased in urticarial reactions, mastocytosis, and basophilia. Histamine also acts as a neurotransmitter in the central nervous system (CNS). Upon release from its storage sites, histamine exerts effects ranging from mild irritation and itching to anaphylactic shock and eventual death. 

One in 10 persons, 22 million people, in the United States have allergies. Ten million of these suffer from the nasal discomfort of "hay fever" and six million from die more serious asthma. Substantial numbers of people in the United States die of allergic reactions to insect stings (more than 30 per year) or to injections of penicillin (300 per year in 1970). Foods, drugs, pollens, mold spores, mites in house dust, and even heat or cold can evoke serious allergic reactions. Among these eczema (atopic dermatitis) is very common. A major cause of allergic reactions has been... 

Usually, but not invariably, dermatologic lesions are restricted to light-exposed areas. Changes may vary from urticaria to papular and eczematous eruptions with subsequent exfoliation and lichenification. Microscopically, it is very difficult to distinguish photoallergic reactions from nummular eczema, atop dermatitis, eczematous drug eruptions, and, especially, allergic contact dermatitis. 

III) The symptoms correspond to a well-known allergic reaction to the specific drug, e.g., maculopapular rash, allergic contact eczema... 

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