Early growth-regulated genes

Some of the genes that are commonly regulated by all three arAR subtypes have also been previously identified with traditional methods of detection. Common transcription factors such as c-fos and c-jun (14) as well as the early growth response genes (egr-1) (15) have been found to increase after arAR activation. 

The mutations can lead to changes in the alignment of genes with products involved in signal transduction pathways and in growth regulation. It is assumed that these mutations are particularly important in the early phase of tumor formation. 

Ishida N, Miyazaki K, Sakai T 2001 Circadian rhythm biochemistry from protein degradation to sleep and mating. Biochem Biophys Res Commun 286 1—5 Kloss B, Price JL, Saez L et al 1998 The Drosophila clock gene double-time encodes a protein closely related to human casein kinase lepsilon. Cell 94 97—107 Lau LF, Nathans D 1987 Expression of a set of growth-related immediate early genes in BALE/ c 3T3 cells coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 84 1182-1186... 

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