Dysmenorrhoea, NSAIDs

They are useful in relieving all dull itching, throbbing pain of muscles and joints, dysmenorrhoea, toothache, headache etc. The NSAID s are the mainstay for the management of acute dental pain. 

First statement Aspirin and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs) and theoretically the best OTC analgesics for dysmenorrhoea. Second statement NSAIDs act by promoting the action of the enzyme cyclooxygenase, thus preventing the formation of prostaglandin endoperoxides from arachidonic acid produced when tissue is damaged. 

It is a non-steroidal antiinflammatory drug (NSAID) and used mainly as its sodium salt for the relief of pain and inflammation in various conditions, such as musculoskeletal and joint disorders viz., rheumatoid, arthritis, osteoarthritis and ankylosing spondolytis peri-articular disorders, for instance bursitis and tendenitis soft-tissue disorders, such as sprains and strains and other painful conditions, namely renal colic, acute gout, dysmenorrhoea, and following certain surgical procedures. 

NSAIDs soon found novel use in many clinical conditions. Patency of the ductus arteriosus in neonates, mastocytosis, dysmenorrhoea and other conditions are often remarkably improved by these drugs. At the same time, many adverse effects of NSAIDs can be interpreted as due to inhibition of prostaglandin synthesis. In gynaecology, for example, NSAIDs were thus found to delay parturition and cause haemorrhagic complications in the mother, and to induce premature closure of the ductus arteriosus in the infant (for reviews see refs. 79 and 80). 

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