Fijian sample

Dysidazirine 130 was isolated by Ireland in 1988 from a Fijian sample of the marine sponge Dysidea fragilis [194] as the major lipophilic component of the sponge and was shown to possess cytotoxic activity against L1210 cells, as well as... 

Varacin (114), a cytotoxic compound closely related to lissoclinotoxin A (106), was isolated from a Fijian sample of L vareau and a benzopentathiepin structure was proposed on the basis of spectral data [131]. Two total syntheses of varacin (114) have been carried out [132,133] and later, further syntheses were described [134-135]. N,N-dimethyl-5-(methylthio)varacin (115) and the corresponding trithiane (116) were obtained from L. japonicum from Palau and 3,4-desmethylvaracin (117) was isolated from a Eudistoma sp. from Pohnpei [136], An inseparable mixture of 5-(methylthio)varacin (118) and the corresponding trithiane (119) was obtained from a Pohnpeian Lissoclinum sp. [136]. Three additional antimicrobial polysulfides of the varacin family (120-122) were isolated from Polycitor sp., collected by dredging in the Sea of Japan [137]. 

Chemical study of a marine-derived Penicillium brocae, obtained from a tissue sample of a Fijian Zyzzya sp. sponge, resulted in the isolation and characterization of three novel cytotoxic polyketides, brocaenols A-C 136, 137a, and 137b, possessing an unusual enolized oxepine lactone ring system <2003JOC2014>. 

FIGURE 22.10 In vitro cell assay of HPLC fractionation products (0.5 min/fraction) from Pacific ciguatoxi-cosis case sample 061001, Fijian coral cod (C. miniata). 

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