Dysbindin association with schizophrenia

Many of the genes that increase vulnerability to bipolar disorder are common to schizophrenia but some genes appear to be unique to each disorder. Genome-wide association studies of psychotic bipolar disorder have shown replicated linkage to chromosomes 8p and 13q. Several candidate genes have shown association with bipolar disorder with psychotic features and with schizophrenia. These include genes for dysbindin, DAOA/G30, disrupted-in-schizophrenia-1 (DISC-1), and neuregulin 1. 

As noted earlier (see O Section 2.2.63.i), dysbindin-lB in human synapses is almost exclusively associated with synaptic vesicles. Consequently, our recent finding that dysbindin-lB is reduced in the hippocampal formation of schizophrenia cases confirms our previous quantitative immunohistochemi-cal finding that reduced dysbindin-1 occurs in glutamatergic presynaptic fields of associational and... 

Donohoe G, Morris DW, Clarke S, McGhee KA, Schwaiger S, et al. 2007. Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia A preliminary study. Neuropsychologia 45 454-458. 

Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, et al. 2003. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 72 185-190. 

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