During irregular intake

Time Course of Drug Plasma Levels During Irregular Intake (B)... 

The nurse inspects the IV needle site every 30 minutes for signs of extravasation. Potassium is irritating to the tissues. If extravasation occurs, the nurse discontinues the IV immediately and notifies the primary health care provider. The acutely ill patient and the patient with severe hypokalemia will require monitoring of the blood pressure and pulse rate every 15 to 30 minutes during the time of the IV infusion. The nurse measures the intake and output every 8 hours. The infusion rate is slowed to keep the vein open, and the primary health care provider is notified if an irregular pulse is noted. 

Although alcohol is considered to be the number one civilisation drug, it is also an integral part of human existence, unless its use is prohibited by strict religious laws or a fundamental attitude to life. A moderate and careful approach towards alcohol is thus called for. As a rule of thumb for the use of alcohol, one could say Drink moderately, but not on a daily basis. During abstinence, the liver enjoys the possibility of full recovery daily alcohol intake inhibits protein synthesis in the liver cells as well as cell recovery. Furthermore, any risk of addiction is avoided if alcohol is only consumed in an irregular manner (= interposed days of abstention). 

Chronic fluoride intoxication is more common and, since fluoride is concentrated in the hard tissues, the bones and teeth show the most obvious effects of fluorosis. Intake of excessive amounts of fluoride during tooth development results in mottled enamel which is characterized by the presence of scattered irregular white flecks. The permanent teeth are particularly susceptible. Towards the end of the last century this condition was found to be of common... 

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