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DUMP suppression test

The dUMP Suppression Test Rapidly dividing ceUs can either use preformed TMP or can synthesize it de novo from dUMP. Isolated hone marrow cells or stimulated lymphocytes incubated with pH]TMP wUl incorporate label into DNA. In the presence of adequate amounts of methylene-tetrahydrofolate, the addition of dUMP as a substrate for thymidylate synthetase reduces the incorporation of pH] TMP as a result of dUution of the pool of labeled material by newly synthesized TMP. [Pg.289]

A serum concentration of vitamin B below llOpmol/L is associated with megaloblastic bone marrow, incipient anaemia and myelin damage. Below 150pmol/L there are early bone marrow changes, abnormalities of the dUMP suppression test (section 11.11.6.2) and methylmalonic aciduria after a valine load (section 11.10.2). [Pg.384]

See other pages where DUMP suppression test is mentioned: [Pg.315]    [Pg.317]    [Pg.317]    [Pg.315]    [Pg.317]    [Pg.317]    [Pg.315]    [Pg.317]    [Pg.317]   
See also in sourсe #XX -- [ Pg.289 , Pg.292 , Pg.317 ]

See also in sourсe #XX -- [ Pg.289 , Pg.292 , Pg.317 ]

See also in sourсe #XX -- [ Pg.289 , Pg.292 , Pg.317 ]

See also in sourсe #XX -- [ Pg.394 ]



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